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Anti-inflammatory function Barrel packaging Packaging: Bag in bag Test 1: High performance liquid chromatography Test 2: Nrm Brand: Aluminium foil package Transport packaging: aluminium foil bag Specification: Aluminium foil package Place of origin: Hubei, China HS code: 000000 Function: Anti-inflammatory Packaging: Drum Packaging: Bag and pouch Test 1: High performance liquid chromatography Test 2: Nrm Label: Aluminium foil bag Transport packaging: Aluminium foil bag Specification: Aluminium foil bag Place of origin: Hubei, China HS code: 000000 High quality chamomile extract apigenin powder Apigenin also stimulates adult neurogenesis, Apigenin "can be used to stimulate adult neurogenesis and treat neurological diseases, disorders and injuries by stimulating the production of neuronal cells in the adult brain". By influencing cell signalling, inflammation, the cell cycle and protease production, apigenin has been shown to be effective in a number of cancers. We are also the holders of the rights to : Amygdalin almond extract 29883-15-6 Aloe vera extract Astaxanthin 472-61-7 Avocado Soya Nesaponifiable Beans Broccoli extract powder Ecdysone extract 5289-74-7 Epimedium extract powder Morinda root extract Garcinia cambogia extract 90045-23-1 Ginseng extract Grape seed extract powder 84929-27-1 Green coffee beans Green tea powder Morinda extract Mulberry extract Olive leaf extract Pterostilbene 537-42-8 Rhodiola rosea 97404-52-9 Sulforaphane 4478-93-7 Tribulus Terrestris Apigenin 520-36-5 Mangiferin 4773-96-0 Lycopene 502-65-8 Zeaxanthin 144-68-3 Xanthophyll 127-40-2 Chrysanthemum indicum extract Svertiamarin 17388-39-5 Celastrol 34157-83-0 High-quality apigenin powder from chamomile extract Apigenin may also stimulate neurogenesis in adults, Apigenin may be useful "to stimulate neurogenesis in adults and to treat neurological diseases, disorders and injuries by stimulating the formation of neuronal cells in the adult brain". Thanks to its effects on cell signalling, inflammation, the cell cycle and protease production, apigenin has been shown to be effective against various cancers.

Orange juice production is the main driving force and development direction of China's citrus industry. A large number of epidemiological studies and animal experiments have shown that citrus fruits have antioxidant, anticancer, preventive, anti-allergic and antibacterial effects. This is mainly because citrus fruits contain flavonoids (80%), mainly flavonoids, of which hesperidin and naringin are the most important flavonoids in citrus fruits. Hesperidin has antioxidant, anti-inflammatory and analgesic, immunomodulatory and anti-tumour effects. Naringin has strong biological properties such as hypolipidemic, sedative, antioxidant, antitumour, antifungal and anti-atherosclerotic. Detecting and controlling the contents of the two flavonoid active ingredients in orange juice beverages is of positive significance for improving the value of orange juice beverages, standardising consumption and promoting industrial development. The contents of hesperidin and naringenin can be determined by LUMEX capillary electrophoresis, an assay that involves separating different components of the beverage by capillary electrophoresis and absorbing these components at 220 nm.

Citrus Aurantium Extract Diosmin is a venotonicity enhancing drug and vasoprotective agent that improves the function of the venous, lymphatic and microcirculatory systems. Its chemical formula is C28H32O15 and molecular weight is 608.54. It is soluble in dimethyl sulfoxide and strong alkaline solution, insoluble in water, methanol or ethanol, and very slightly soluble in 0.1 mol/L sodium hydroxide. Its mechanism of action is mainly as follows For the venous system, it can prolong the time when adrenaline acts on the venous wall to cause contraction, thus enhancing venous tone. For the microcirculatory system, it can reduce the permeability of capillaries and enhance their resistance, preventing the exudation of water and protein. For the lymphatic system, it can increase the lymphatic drainage rate and lymphatic vasoconstriction, improve lymphatic reflux and reduce edema. In addition, it can inhibit the release of inflammatory mediators, reduce the adhesion and aggregation of leukocytes and platelets, and prevent thrombosis. Diosmin has a variety of pharmacological effects, which are mainly manifested: Enhancing venous wall tone and elasticity, reducing venous distensibility and venous stasis. Reducing the viscosity of the blood and increasing the flow rate reducing stagnation. Normalizes capillary wall permeability and increases its resistance. Enhances lymphatic constriction and lymphatic drainage rate, accelerates reflux reduces edema. Inhibits leukocyte adhesion and migration to endothelial cells to reduce inflammatory response. Inhibit the production and damage of free radicals, with antioxidant effect. Diosmin is mainly used for the treatment of various symptoms related to venous and lymphatic insufficiency (such as venous edema, soft tissue swelling, heaviness, numbness, pain in the limbs, morning sickness, thrombophlebitis and deep vein thrombosis syndrome, etc.), and for the treatment of symptoms related to acute hemorrhoidal attacks (such as anus moisture, itching, blood in stool, pain and other symptoms of acute attacks of internal and external hemorrhoids caused by hemorrhoidal varicose vein ). It is usually taken orally as a tablet or capsule, usually one or two capsules twice daily. Prospects for the use of Diosmin Its application prospect is relatively broad, as it can effectively improve various clinical problems caused by venous dysfunction, and has a good safety and tolerability. At present, Diosmin has been widely used in the treatment of varicose veins of the lower limbs, acute or chronic hemorrhoids, lymphatic reflux disorders, lymphedema, peripheral skin ulcers and other diseases. In addition, Diosmin has the potential to be used in the treatment of other diseases related to abnormal vascular function, such as hypertension, coronary heart disease, stroke, diabetes mellitus, etc., which are all directions worthy of further exploration and research. It is currently mainly derived from the semi-synthesis of hesperidin extracted from natural plants. Although this method can ensure the naturalness and biological activity of Diosmin, it also has some drawbacks, such as restricted raw material sources, higher cost, and the purity is not easy to control. Therefore, finding a method to synthesize Diosmin is an important topic. Currently, some methods for synthesizing deosmin have been proposed and implemented, but they still need to be improved and optimized. In the future, if an efficient, low-cost and high-purity synthesis of diosmet can be realized, it will bring more convenience and advantages for its clinical application.

Citrus fruit peels are rich in hesperidin, and other herbal medicines rich in hesperidin include Citrus aurantium and Pericarpium Citri Reticulatae. Chen Pi and Hovenia Citriodora are one of the main herbs in the Chinese herbal compound formulae recommended in the Chinese Medicine section of the Diagnostic and Treatment Program for Novel Coronavirus Pneumonia (Trial Seventh Edition) (p. 16). Citrus aurantium is the dried young fruit of Citrus aurantium L. and its cultivated varieties or Citrus sinensis Osbeck, a plant of the Brassicaceae family, and the dried young fruit of Citrus sinensis Osbeck, a sweet orange. fruits are collected from falling in May to June, impurities are removed, and the fruits are cut horizontally from the center in two halves, dried in the sun or at low temperatures, and the smaller ones are directly dried in the sun or at low temperatures. Mainly produced in Sichuan, Jiangxi, Hunan, Hubei, Jiangsu. From the perspective of traditional Chinese medicine, Hovenia dulcis and Sarcophagus have similar functions and are often used to treat stomach disorders. Because of the bitter taste and cold nature of Hovenia, attributed to the large intestine meridian, the spleen meridian and the stomach meridian, can play a role in eliminating food and phlegm, the effect of abdominal qi, for the stomach bloating, indigestion, etc. have a certain role in regulating. By now, there are many proprietary Chinese medicines for treating gastric dysfunction, which can also be found in Hovenia. The article analyzed the content of hesperidin contained in orange peel and pointed out that hesperidin may disrupt the interaction of RBD with ACE2 (the human receptor for neocoronaviruses) by binding to the neocoronavirus S-protein receptor-binding structural domain (RBD) and thus disrupting the interaction of RBD with ACE2. Hesperidin is a flavonoid found in citrus fruits such as mandarin, lemon or grapefruit fruits. Hesperidin is most abundant in the rind and membranous parts of these fruits, especially in small unripe citrus fruits. It is one of the color and flavor components of citrus fruits. Flavonoid hesperidins are flavanone glycosides (glucosides) composed of flavanones (a flavonoid) graminic acid and disaccharide brassinolide. Flavonoids are polyphenols, antioxidants found in plants that are essential to human health. In addition to its antioxidant properties, hesperidin is used as an anti-inflammatory, anti-allergic, hypolipidemic, and vasoprotective compound. It appears to reduce the symptoms of allergies and hay fever by inhibiting the production of histamine in the blood. Pharmacologic Activity of Hesperidin: (1) Hesperidin is a treatment for hypertension and myocardial infarction, and is used in the pharmaceutical industry as a raw material for making medicines, and is one of the main components of the proprietary Chinese medicine, Pulsatilla. (2) Hesperidin has anti-lipid oxidation, scavenging oxygen free radicals, anti-inflammatory, anti-viral, antibacterial effects, long-term use can delay aging and anti-cancer. In conclusion, hesperidin is a flavonoid compound with precise pharmacological activity and wide range of functions. In addition to its use in medicine, it also has a wide range of uses in sports pharmacy and sports nutrition, so it has a broad prospect for development and utilization, and its related research work is expected to be further carried out in depth and systematically. Hesperidin has the function of maintaining osmotic pressure, enhancing capillary toughness, shortening bleeding time and lowering cholesterol, etc. It is clinically used in the adjuvant treatment of cardiovascular system diseases, and it can be used to cultivate many kinds of medicines for preventing atherosclerosis and myocardial infarction, and it is one of the main raw materials for the medicine "Pulse Tong". It can be used as natural antioxidant in food industry. It can also be used in cosmetic industry. Hesperidin mostly exists in the waste of citrus processing, such as peel, fruit capsule, in which the highest content of hesperidin is found in the ripe peel and tissues (30%-50% in endocarp, 30%-50% in orange complexes, nuclei, pulp, and 10%-20% in exocarp), and the content of juice and orange capsule is lower 1%-5%. Hesperidin extraction methods include solvent extraction, alkali acid precipitation, carbon adsorption, ion exchange, of which the alkali acid precipitation method is simple, low-cost, high extraction rate. Hesperidin is soluble in dilute alkali and pyridine and hot water above 70℃, slightly soluble in methanol, almost insoluble in acetone, benzene and chloroform. The extraction of hesperidin mainly utilizes the two phenolic hydroxyl groups it contains to react with sodium ions in solution under alkaline conditions to generate sodium salts which are dissolved, then acidified and cooled to precipitate them out of solution. Extraction of hesperidin from citrus peel is generally done by heat extraction and immersion extraction, both of which have unsatisfactory yields. In recent years, ultrasonic extraction of active ingredients in natural plants (especially Chinese herbs) has been widely studied, and some progress has been made. The use of hesperidin under alkaline conditions for extraction by open-loop dissolution, acidic conditions for separation by closed-loop precipitation, increase the amount of alkali during extraction can reduce the amount of ethanol, but the alkalinity should not be too large, otherwise, the hesperidin is easy to oxidize and destroy.

Related Research. If we are now to look at the human evidence for oral hesperidin, it appears to promote blood flow (mildly to moderately) and may have a weaker effect on blood pressure. That said, oral hesperidin at doses similar to those used in humans appears to be a very potent cardioprotective agent in animal studies and has comparable brain protection against a variety of stressors; the protection is essentially antioxidant in nature but appears to work through a currently uncharacterized genomic antioxidant response. In addition to its protective effects (most notably in the heart and brain, but essentially extending to every organ), hesperidin may be able to reduce loss of appetite and have less antiallergic properties. 0.1-1 mg/kg hesperidin (intraperitoneal) appears to have an antidepressant mechanism, is metabolized through κ-opioid receptors without inhibiting signaling through δ-opioids, μ-opioids, or peripherally-acting κ-opioid antagonists or caffeine adenosine, caffeine, and possibly opioid receptors, and at a sub-effective dose of hesperidin (10 μg/kg intraperitoneal) appears to have a synergistic effect with morphine has a synergistic effect. In isolated PC12 cells, low concentrations (100-1000 nM) of hesperidin were found to activate neuronal growth factors (Akt/ERK and CREB) and antioxidant factors (seladin-1 and PGC-1α) in a manner that was dependent on TrkA receptors and estrogen signaling. Due to the neuroprotective effects of estrogen associated with Akt and seladin-1, it is thought that seladin is an estrogen mimetic with neuroprotective effects, although all of these effects are dependent on two factors (TrkA and estrogen signaling), and the increase in seladin-1 is entirely dependent on estrogen signaling. Injection of 0.1-1 mg/kg hesperidin (intraperitoneal) to mice subjected to the stress swim test was able to exert antidepressant effects, whereas 10 μg/ kg was ineffective by itself, and this has been replicated elsewhere in the forced swim and tail suspension tests, with potency comparable to promethazine (15 mg/kg injectable) and fluoxetine (32 mg/kg injectable), at doses of 0.3- 1mg/kg. In one study, intraperitoneal injections of hesperidin (0.1-1mg/kg) were found to provide antidepressant effects but no significant anxiolytic effects, and forced anxiolytic effects could be produced in mice with high doses of hesperidin injections (2-30mg/kg) during oral ingestion of 20-100mg/kg of hesperidin, which is thought to be related to opioid receptor signaling. Unless injected at high doses, hesperidin does not appear to have sizable but inherent anxiolytic properties. It appears that under the specific condition of stress-induced nerve damage leading to anxiety, there may be anxiety-reducing properties because the damage is attenuated by hesperidin (and anxiety is reduced due to less damage). Rats administered orally at 5 mg/kg (in which anorexia was induced with cisplatin) appeared to reduce the reduction in food intake observed with cisplatin by 59%. Hesperidin has been shown to positively inhibit anorexia after oral administration in a manner thought to be mediated by 5-hydroxytryptamine signaling and dependent on the action of growth hormone. Hesperidin given orally at 100 mg/kg for 90 days to young and aged rats was able to partially reverse the deterioration of antioxidant enzymes seen in cardiac tissue during aging, whereas changes in these enzymes were not significant in young hearts; lipid peroxidation and protein carbonylation, which is thought to be due to the increased expression of Nrf2 in aging hearts that decreases with aging (and does not increase in the young). Hesperidin appears to protect the heart after oral administration of various stimulants and can work in a preventive or rehabilitative manner within a week. Although there are no human studies available, it appears to be surprisingly effective in reducing lipid peroxidation and markers of cardiotoxicity. In hyperlipidemia (baseline TG above 150 mg/dL) given 500 mg G-hesperidin daily for 24 weeks, serum triglycerides were significantly reduced (up to 34%) after four weeks, which were maintained at a fixed magnitude at 24 weeks of supplementation and normalized to baseline values after four weeks of cessation. In mice that suffered frostbite (tibia) and were subsequently injected with hesperidin at a dose of 50 mg/kg for six days, muscle regeneration appeared to be significantly enhanced compared to controls. In healthy rats given 0.5% hesperidin (55mg/kg) in the diet for three months a study noted that in adolescent rats, but not older rats, hesperidin intake resulted in increased bone growth. In young rats, a relatively reasonable dose of hesperidin (found in supplements or orange peels) increased the rate of bone growth; this increase in bone growth rate was not seen in older adults with fully developed bones. In male mice given hesperidin (0.5%) or G-hesperidin (0.7% diet) for 4 weeks, bone loss associated with androgen deficiency was reduced relative to controls. Oral supplementation with 0.5% hesperidin (approximately 55 mg/kg) in ovariectomized rats (a model of menopause) was able to partially attenuate bone loss seen from ovariectomy, with no significant effect on uterine weights, suggesting no associated estrogenic effect; these effects were associated with a plasma concentration of 3.57 +/- 0.68 μM hesperidin. Hesperidin appears to orchestrate the increase in antioxidant defenses and pro-survival proteins through estrogen signaling and TrkA (BDNF receptor) acting, which is thought to be the mechanism for inhibiting oxidative toxin or stressor-induced cell death. In irradiated rats (resulting in reduced mitochondrial capacity of the brain and reduced neurotransmitter levels due to oxidative damage), daily oral ingestion of 50 mg/kg of hesperidin before and two weeks after 10 days of irradiation was able to attenuate oxidative (40% reduction in thiols) and neurotransmitter changes (49-60% attenuation), whereas in the absence of radiation, hesperidin had no effect. Mitochondrial capacity is known to be maintained with a two-week preload (50-100 mg/kg in mice) prior to immobilization stress testing (which is known to increase NOS activity). In the brain, hesperidin appears to have an antioxidant effect, in which hesperidin reduces the increase in lipid peroxidation during cognitive impairment, but this appears to be an indirect effect through nitric oxide signaling (inhibition) rather than a direct antioxidant effect. Hesperidin appears to have multiple neuroprotective effects at relatively standard oral doses, and these also appear to be dependent on inhibiting faulty nitric oxide signaling (leading to antioxidant and anti-inflammatory defenses).

In recent years, with people's pursuit of a healthy life and emphasis on cancer prevention, more and more natural ingredients and herbs are attracting attention for their potential anti-cancer effects. Recently, a CCTV report triggered the attention of the general public that "naringenin", a natural ingredient in Chenpi, has been found to have a cancer-preventive effect by research. Chenpi, as a traditional Chinese herbal medicine and a common seasoning in cooking, has always been loved by people for its unique aroma and medicinal value. And this CCTV report has added a layer of mystery to Chenpi. According to the CCTV report, naringenin is an important active ingredient in Chenpi, which has a variety of biological activities such as antioxidant, anti-inflammatory, anti-tumor and so on. Studies have shown that naringenin can inhibit the growth and spread of tumor cells and induce apoptosis of tumor cells, thus achieving the effect of cancer prevention. The mechanism of action of naringenin in preventing cancer is mainly related to its antioxidant and anti-inflammatory effects. In modern life, environmental pollution, bad habits and other factors lead to a large number of free radicals and inflammatory factors in the body, these substances will damage cell DNA, increasing the risk of cancer. Naringenin, on the other hand, is able to remove free radicals and reduce inflammatory reactions, thus protecting cells from damage and preventing cancer. In addition to preventing cancer, naringenin has a variety of other health benefits. Studies have shown that naringenin can lower blood pressure, regulate blood lipids, and improve cardiovascular health. Therefore, consuming naringenin-containing peels in moderation not only prevents cancer, but also maintains overall health. Of course, in order to fully utilize the anti-cancer effect of naringenin in tangerine peel, it is also necessary to pay attention to moderate consumption and reasonable combination. Excessive consumption of tangerine peel may lead to some adverse reactions, such as dry mouth and bitter taste. Therefore, when using tangerine peel in cooking, it should be added in moderation according to personal taste and health condition.

Lemon flavonoids have antiviral and antibacterial properties, among which hesperidin is one of the main components of lemon flavonoids, with high medicinal value. It has the effects of relieving cough and asthma, maintaining normal osmotic pressure of blood vessels, reducing vascular fragility, and shortening bleeding time. Hesperidin has a first excitatory and then inhibitory effect on isolated intestinal tubes, which is a vitamin P-like effect. Hesperidin and naringin have anti-inflammatory effects and have the same effect as paeoniflorin in peony. They are also the main raw materials for synthesizing a new type of high sweetness, low calorie sweetener, dihydrochalcone. Lemon flavonoids have special effects in clearing free radicals, improving immunity, and anti-tumor effects. Elderly health products made from lemon flavonoids have the effects of prolonging life and preventing aging Store in a cool and ventilated warehouse, away from ignition and heat sources, and avoid direct sunlight.

1. Effective antioxidants: Numerous studies have shown that citrus flavonoids are an effective antioxidant. Researchers have found that increasing the intake of bioflavonoids can help reduce the harm caused by free radicals to the human body. The antioxidant and anti-inflammatory effects of citrus flavonoids have been proven to promote human metabolism, circulation, cognition, and joint health. In addition, citrus flavonoids can balance immune cell activity, promote immune response and respiratory health. 2. Multifunctionality: Citrus bioflavonoids can be used for immune system, respiratory system, cognitive health, vascular health, metabolism, cholesterol, joint health, and systemic antioxidant properties. Its versatility makes it an ideal ingredient for food, beverage, and dietary supplement applications. They can be suspended in liquids, so they can be used in various beverages; They can provide bitterness and sourness for specific beverages, including beer; They also serve as natural preservatives, providing the benefit of extending shelf life for food and beverage products. 3. Anti inflammation: A study in the review of Food Science and Nutrition shows that citrus flavonoids have more prominent anti-inflammatory properties in anti-inflammatory, antioxidant, lipid-lowering, and insulin sensitivity improvement. The study in the journal Progress in Nutrition observed the biological activity of citrus flavonoids, particularly their effects on lipid metabolism in obese individuals, oxidative stress, and inflammation in patients with metabolic syndrome. The results indicate that citrus flavonoids have strong anti-inflammatory and antioxidant activities. A study in Inflammatory Mediators suggests that flavonoids have a relieving effect on allergic asthma. In a mouse asthma model, it showed a significant inhibitory effect on respiratory inflammation.

Natural & Nutraceutical Products China Guangzhou (NPC) 2017 will be held on 12-14 December 2017 at PWTC Expo, Guangzhou. NPC 2017 targets the middle and high end nutritional and health products market and aims to promote the development of China`s grand health industry. Making use of the experience in successfully holding the HNC Shanghai for six years and integrating the quality resources nationwide, the organizer will widely recruit health product dealers, agents, retail stores, chain drugstores, supermarkets and other buyers to assist the exhibitors to explore the health product market in the Pearl River Delta, expand channels, establish brand image and build a professional trade platform.